湖州师范学院党委宣传部、消息中央主理

Tea Time学术运动—公派访学申报

来源:澳门游戏厅 宣布日期>2019-07-23

申报题目: Dynamics of Context-Dependent Microbial Consortium of Predator and Prey

报 告 人: 毛俊雯 (传授)

时    间:7月2号 (周二) 150016:00

地    点:2019-07-231 物理学科集会室

        Abstract Synthetic microbial consortia are a rapidly growing area of synthetic biology. So far, most consortia are designed without considering their environments; however, in nature, microbial interactions are constantly modulated by cellular contexts, which in principle can alter community behaviors dramatically. Here we present the construction, validation and characterization of an engineered bacterial predator-prey consortium that involves a chloramphenicol(CM)-mediated, context-dependent cellular interaction. By conducting the experiments and the simulations of mathematical models, we show that varying the CM level in the environment can induce the ecosystem to success with distinct patterns from prey dominance to prey-predator crossover and to ecosystem collapse, We also illustrate that such a dependence enriches community dynamics under different initial conditions and further test the resistance of the consortium to invasion with engineered bacterial strains. This workexemplifies the role of the context-dependence of microbial interactions in moderating ecosystem dynamics, underscoring the importance to include contexts into the design of engineered ecosystems for synthetic biology applications.

 

        申报人简介:毛俊雯,博士,传授。1992年获中国迷信技能大学学士学位,2006年6月获浙江大学物理学博士学位。1998年起在湖州师范学院任教,重要研究领域:非均衡统计物理成就、基因收集调控的随机能源学。2007年被选浙江省高等黉舍青年教师帮助计划帮助,2013年被选浙江省高校中青年学科带头人,2017年获“湖州师范学院第四届陆增镛教师奖”,现担负浙江省“十三五”特色专业卖力人,浙江师范大学兼职硕士生导师。2018年3-8月由国度留学基金委帮助赴美国伊利诺伊大学香槟分校学术交换。比年来在ACS Synth. Biol.,Biophys. J.,Phys. Rev. E,Europhys. Lett.等国内外刊物上发表SCI论文20多篇,出版学术译著1部,掌管国度自然迷信基金项目4项,此中在研面上项目1项。